Prion Proteins with Pathogenic and Protective Mutations Show Similar Structure and Dynamics

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Self-similar fractals and arithmetic dynamics

‎The concept of self-similarity on subsets of algebraic varieties‎ ‎is defined by considering algebraic endomorphisms of the variety‎ ‎as `similarity' maps‎. ‎Self-similar fractals are subsets of algebraic varieties‎ ‎which can be written as a finite and disjoint union of‎ ‎`similar' copies‎. ‎Fractals provide a framework in which‎, ‎one can‎ ‎unite some results and conjectures in Diophantine g...

متن کامل

Molecular dynamics as an approach to study prion protein misfolding and the effect of pathogenic mutations.

Computer simulation of protein dynamics offers unique high-resolution information that complements experiment. Using experimentally derived structures of the natively folded prion protein (PrP), physically realistic dynamics and conformational changes can be simulated, including the initial steps of misfolding. By introducing mutations in silico, the effect of pathogenic mutations on PrP confor...

متن کامل

The consequences of pathogenic mutations to the human prion protein.

Prion diseases, in which the conformational transition of the native prion protein (PrP) to a misfolded form causes aggregation and subsequent neurodegeneration, have fascinated the scientific community as this transmissible disease appears to be purely protein-based. Disease can arise due to genetic factors only. At least 30 single point mutations have been indicated to cause disease in humans...

متن کامل

a comparison of teachers and supervisors, with respect to teacher efficacy and reflection

supervisors play an undeniable role in training teachers, before starting their professional experience by preparing them, at the initial years of their teaching by checking their work within the proper framework, and later on during their teaching by assessing their progress. but surprisingly, exploring their attributes, professional demands, and qualifications has remained a neglected theme i...

15 صفحه اول

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Biochemistry

سال: 2009

ISSN: 0006-2960,1520-4995

DOI: 10.1021/bi900923b